ANGPTL2

ANGPTL2
Identifikatori
Aliasi	ANGPTL2
Vanjski ID-jevi	OMIM: 605001 MGI: 1347002 HomoloGene: 22695 GeneCards: ANGPTL2
Lokacija gena (čovjek)
Hrom.	Hromosom 9 (čovjek)
Kraj	127,122,635 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	33,137,729 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• signaling receptor binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• extracellular region; • Egzosom; • Vanćelijsko; • collagen-containing extracellular matrix;
Biološki proces	• multicellular organism development;
	Izvori:Amigo / QuickGO
Ortolozi
	23452
	26360
	ENSG00000136859
	ENSMUSG00000004105
	Q9UKU9
	Q9R045
	NM_012098
	NM_011923
	NP_036230
	NP_036053
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 2 srodan angiopoetinu, znan i kao angiopoetinoliki protein 2 je protein koji je kod ljudi kodiran genom ANGPTL2.^[5]^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 493 aminokiseline, а molekulska težina 57 104 Da.^[7]

10	20	30	40	50
MRPLCVTCWW	LGLLAAMGAV	AGQEDGFEGT	EEGSPREFIY	LNRYKRAGES
QDKCTYTFIV	PQQRVTGAIC	VNSKEPEVLL	ENRVHKQELE	LLNNELLKQK
RQIETLQQLV	EVDGGIVSEV	KLLRKESRNM	NSRVTQLYMQ	LLHEIIRKRD
NALELSQLEN	RILNQTADML	QLASKYKDLE	HKYQHLATLA	HNQSEIIAQL
EEHCQRVPSA	RPVPQPPPAA	PPRVYQPPTY	NRIINQISTN	EIQSDQNLKV
LPPPLPTMPT	LTSLPSSTDK	PSGPWRDCLQ	ALEDGHDTSS	IYLVKPENTN
RLMQVWCDQR	HDPGGWTVIQ	RRLDGSVNFF	RNWETYKQGF	GNIDGEYWLG
LENIYWLTNQ	GNYKLLVTME	DWSGRKVFAE	YASFRLEPES	EYYKLRLGRY
HGNAGDSFTW	HNGKQFTTLD	RDHDVYTGNC	AHYQKGGWWY	NACAHSNLNG
VWYRGGHYRS	RYQDGVYWAE	FRGGSYSLKK	VVMMIRPNPN	TFH

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Funkcija

Protein 2 sličan angiopoetinu održava homeostazu tkiva podstičući adaptivnu upalu i kasniju rekonstrukciju tkiva, dok višak aktivacije ANGPTL2 izazvan produženim stresom podstiče narušavanje homeostaze tkiva zbog hronične upale, podstičući razvoj metaboličkih bolesti. ANGPTL2 ima ulogu i u angiogenezi, u popravljanju tkiva, u gojaznosti, u ateroskleroznim bolestima i na kraju u karcinogenezi.^[8]

Angiopoietini su članovi porodice faktor rasta vaskularnog endotela i jedini poznati faktori rasta koji su uglavnom specifični za vaskularni endotel. Angiopoietin-1, angiopoietin-2 i angiopoietin-4 učestvuju u stvaranju krvnih sudova. ANGPTL2 protein je izlučeni glikoprotein s homologijom na angiopoetine i može djelovati na endotelne ćelije, djelovanjem autokrino ili parakrino.^[6]

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000136859 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004105 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kim I, Moon SO, Koh KN, Kim H, Uhm CS, Kwak HJ, Kim NG, Koh GY (Oct 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol Chem. 274 (37): 26523–8. doi:10.1074/jbc.274.37.26523. PMID 10473614.
1 2 "Entrez Gene: ANGPTL2 angiopoietin-like 2".
↑ "UniProt, Q9UKU9". Pristupljeno 5. 9. 2021.
↑ Kadomatsu, Tsuyoshi; Endo, Motoyoshi; Miyata, Keishi; Oike, Yuichi (maj 2014). "Diverse roles of ANGPTL2 in physiology and pathophysiology". Trends in Endocrinology & Metabolism. 25 (5): 245–254. doi:10.1016/j.tem.2014.03.012. PMID 24746520.

Dopunska literatura

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi:10.1007/s100380300025. PMID 12624729.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Sun H, Zheng JM, Chen S, et al. (2007). "Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy". Nephron Exp. Nephrol. 105 (4): e117–23. doi:10.1159/000100493. PMID 17347581. S2CID 30326676.

Vanjski linkovi

Lokacija ljudskog genoma ANGPTL2 i stranica sa detaljima o genu ANGPTL2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136859 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004105 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10473614-5] Kim I, Moon SO, Koh KN, Kim H, Uhm CS, Kwak HJ, Kim NG, Koh GY (Oct 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol Chem. 274 (37): 26523–8. doi:10.1074/jbc.274.37.26523. PMID 10473614.

[entrez-6] 1 2 "Entrez Gene: ANGPTL2 angiopoietin-like 2".

[UniProt-7] "UniProt, Q9UKU9". Pristupljeno 5. 9. 2021.

[8] Kadomatsu, Tsuyoshi; Endo, Motoyoshi; Miyata, Keishi; Oike, Yuichi (maj 2014). "Diverse roles of ANGPTL2 in physiology and pathophysiology". Trends in Endocrinology & Metabolism. 25 (5): 245–254. doi:10.1016/j.tem.2014.03.012. PMID 24746520.

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