ADAMTS8

ADAMTS8
Pengidentifikasi
Alias	ADAMTS8, ADAM-TS8, METH2, ADAM metallopeptidase with thrombospondin type 1 motif 8
ID Eksternal	OMIM: 605175; MGI: 1353468; HomoloGene: 5108; GeneCards: ADAMTS8; OMA:ADAMTS8 - orthologs
Pola ekspresi RNA
	Ekspresi tertinggi di
	middle temporal gyrus; ; upper lobe of left lung; ; endothelial cell; ; lower lobe of lung; ; right lung; ; Brodmann area 23; ; entorhinal cortex; ; tail of epididymis; ; right coronary artery; ; pleura;
	Ekspresi tertinggi di
	tunica media of zone of aorta; ; lumbar spinal ganglion; ; soleus muscle; ; Pergelangan kaki; ; Atrium (anatomi); ; internal carotid artery; ; endocardial cushion; ; semi-lunar valve; ; inner muscle layer; ; tunica adventitia of aorta;
	Referensi data ekspresi selengkapnya
	n/a
Ontologi gen
Fungsi molekuler	integrin binding; zinc ion binding; peptidase activity; metalloendopeptidase activity; heparin binding; low-affinity phosphate transmembrane transporter activity; metallopeptidase activity; hydrolase activity; metal ion binding;
Komponen seluler	extracellular region; Matriks ekstraseluler; collagen-containing extracellular matrix;
Proses biologis	Proteolisis; negative regulation of cell population proliferation; phosphate ion transmembrane transport;
	Sumber:Amigo / QuickGO
Ortologi
	11095
	30806
	ENSG00000134917
	ENSMUSG00000031994
	Q9UP79
	P57110
	NM_007037
	NM_013906; NM_001326292
	NP_008968
	NP_038934.2
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

A disintegrin and metalloproteinase with thrombospondin motifs 8 adalah enzim yang pada manusia disandi oleh gen ADAMTS8.^[3]^[4]

Fungsi

Gen ini menyandi anggota keluarga protein ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs). Anggota keluarga ini berbagi beberapa modul protein yang berbeda, termasuk daerah propeptida, domain metalloproteinase, domain seperti disintegrin, dan motif thrombospondin tipe 1 (TS). Anggota individu dari keluarga ini berbeda dalam jumlah motif TS C-terminal, dan beberapa memiliki domain C-terminal yang unik. Enzim yang disandi oleh gen ini mengandung dua motif TS C-terminal, dan mengganggu angiogenesis secara in vivo.^[4]

Signifikansi klinis

Sejumlah kelainan telah dipetakan di sekitar gen ini, terutama neoplasma paru-paru.^[4]

Referensi

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)
1 2 3 "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8".

Bacaan lebih lanjut

Wågsäter D, Björk H, Zhu C, et al. (2008). "ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques". Atherosclerosis. 196 (2): 514–22. doi:10.1016/j.atherosclerosis.2007.05.018. PMID 17606262.
Dunn JR, Reed JE, du Plessis DG, et al. (2006). "Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours". Br. J. Cancer. 94 (8): 1186–93. doi:10.1038/sj.bjc.6603006. PMC 2361255. PMID 16570050.
Porter S, Span PN, Sweep FC, et al. (2006). "ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma". Int. J. Cancer. 118 (5): 1241–7. doi:10.1002/ijc.21476. PMID 16152618. S2CID 20711295.
Dunn JR, Panutsopulos D, Shaw MW, et al. (2004). "METH-2 silencing and promoter hypermethylation in NSCLC". Br. J. Cancer. 91 (6): 1149–54. doi:10.1038/sj.bjc.6602107. PMC 2747718. PMID 15328519.
Collins-Racie LA, Flannery CR, Zeng W, et al. (2005). "ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage". Matrix Biol. 23 (4): 219–30. doi:10.1016/j.matbio.2004.05.004. PMID 15296936.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Georgiadis KE, Hirohata S, Seldin MF, Apte SS (2000). "ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11". Genomics. 62 (2): 312–5. doi:10.1006/geno.1999.6014. PMID 10610729.

Pranala luar

Basis data daring MEROPS untuk peptidase dan inhibitornya: M12.226
Lokasi genom ADAMTS8 manusia dan halaman rincian gen ADAMTS8 dalam UCSC Genome Browser.

Artikel ini menggabungkan teks dari Perpustakaan Kedokteran Nasional Amerika Serikat yang berada dalam domain publik. Templat:Metalloproteinases

Artikel bertopik enzim ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10438512-3] Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.{{cite journal}}: Pemeliharaan CS1: Tanggal diterjemahkan otomatis (link)

[entrez-4] 1 2 3 "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8".

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