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. 2000 Jul 14;289(5477):313-6.
doi: 10.1126/science.289.5477.313.

Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9

I López-Coviella  1 , B Berse, R Krauss, R S Thies, J K Blusztajn
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Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9

I López-Coviella et al. Science. .

Abstract

Bone morphogenetic proteins (BMPs) have multiple functions in the developing nervous system. A member of this family, BMP-9, was found to be highly expressed in the embryonic mouse septum and spinal cord, indicating a possible role in regulating the cholinergic phenotype. In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylcholine transporter and up-regulated acetylcholine synthesis. The effect was reversed upon withdrawal of BMP-9. Intracerebroventricular injection of BMP-9 increased acetylcholine levels in vivo. Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons.

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