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. 2009 Dec 14;205(1):315-8.
doi: 10.1016/j.bbr.2009.07.004. Epub 2009 Jul 16.

The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats

Kazuaki Kawaura  1 , Yukino Ogata, Masako Inoue, Sokichi Honda, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Affiliations

The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats

Kazuaki Kawaura et al. Behav Brain Res. .

Abstract

The antidepressant-like effect of tipepidine was studied in rats. Tipepidine at 20 and 40 mg/kg i.p. reduced immobility in the forced swimming test and tipepidine at 40 mg/kg, i.p. increased climbing in the test. The drug at 40 mg/kg, i.p. had no effect on the locomotor activity and motor coordination. These results suggest that tipepidine may be a novel drug with antidepressant-like activity.

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