Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Feb;13(1):64-72.
doi: 10.1007/s11883-010-0149-9.

Are cardiovascular benefits in statin lipid effects dependent on baseline lipid levels?

Keith C Ferdinand  1
Affiliations
Review

Are cardiovascular benefits in statin lipid effects dependent on baseline lipid levels?

Keith C Ferdinand. Curr Atheroscler Rep. 2011 Feb.

Abstract

Statins reduce coronary heart disease (CHD) morbidity and mortality over a wide range of patients. The Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) in subjects with elevated C-reactive protein, without vascular disease and below average low-density lipoprotein cholesterol (LDL-C) showed a 50% reduction in LDL-C with 20 mg/d of rosuvastatin and a reduction in cardiovascular events (hazard ratio 0.56 [95% CI, 0.46-0.69]; P < 0.00001), and a reduction in total mortality (20%; P < 0.02). Recent commentary has criticized perceived JUPITER design flaws and inappropriate influence. However, the Canadian 2009 guidelines cite JUPITER as class I evidence for statin benefit. Although the Cholesterol Treatment Trialists' (CTT) Collaborators showed that, regardless of pre-treatment levels, statins can significantly reduce CHD, major vascular events, and overall mortality, a recent primary prevention meta-analysis showed no decrease in all-cause mortality. Preconceived notions on statin benefit or harm do not enhance patient care and clinicians should individualize long-term statin therapy.

PubMed Disclaimer

References

    1. Can J Cardiol. 2009 Oct;25(10):567-79 - PubMed
    1. Circulation. 2004 Jul 13;110(2):227-39 - PubMed
    1. Circ Cardiovasc Qual Outcomes. 2010 Sep;3(5):447-52 - PubMed
    1. Eur Heart J. 2008 Feb;29(4):499-508 - PubMed
    1. N Engl J Med. 2008 Nov 20;359(21):2195-207 - PubMed

MeSH terms

LinkOut - more resources