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. 2012;14(4):322-6.
doi: 10.1080/10286020.2011.653561.

Total synthesis of 6'-hydroxyjusticidin A

Lu Xiong  1 , Ming-Gang Bi, Song Wu, Yuan-Feng Tong
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Total synthesis of 6'-hydroxyjusticidin A

Lu Xiong et al. J Asian Nat Prod Res. 2012.

Abstract

The first total synthesis of 6'-hydroxyjusticidin A, isolated from Justicia procumbens L. with good inhibitory activity against cancer cells, has been accomplished. The structure was confirmed by ¹H NMR, ¹³C NMR, and HR-ESI-MS. The key steps involved a Diels-Alder cycloaddition reaction and a reduction in NaBH₄.

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