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Review
. 2013;9(9):e1003548.
doi: 10.1371/journal.ppat.1003548. Epub 2013 Sep 26.

Memory of infections: an emerging role for natural killer cells

Alexander Rölle  1 , Julia Pollmann, Adelheid Cerwenka
Affiliations
Review

Memory of infections: an emerging role for natural killer cells

Alexander Rölle et al. PLoS Pathog. 2013.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Memory and memory-like NK cells in mice and humans.
A variety of factors contribute to the generation of memory or memory-like cells. In the mouse, CXCR6+ NK cells from the liver can mediate antigen-specific memory responses against haptens and viral antigens of VSV, HIV, and influenza via a yet-unknown receptor(s). During MCMV infection, the viral m157 protein is recognized by a subset of NK cells carrying the activating Ly49H receptor, resulting in the formation of m157-specific Ly49H+ memory NK cells. Memory-like NK cells in mice and humans can be generated by short-term stimulation with IL-12/15/18. A subset of human NK cells expressing the activating CD94/NKG2C receptor expands in response to the as-yet undefined antigens in HCMV, Hantavirus, Chikungunya Virus, HIV, and HBV infection.
See this image and copyright information in PMC

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