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. 2023 Sep;13(9):e1409.
doi: 10.1002/ctm2.1409.

NLRP12-PANoptosome in haemolytic, infectious and inflammatory diseases

Rebecca E Tweedell  1 , Thirumala-Devi Kanneganti  1
Affiliations

NLRP12-PANoptosome in haemolytic, infectious and inflammatory diseases

Rebecca E Tweedell et al. Clin Transl Med. 2023 Sep.
No abstract available

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Conflict of interest statement

St. Jude Children's Research Hospital filed a provisional patent application on methods for modulating NLRP12, listing Thirumala‐Devi Kanneganti as an inventor (serial no. 63/422,601 and 63/501,430).

Figures

FIGURE 1
FIGURE 1
NLRP12‐mediated PANoptosis drives cytokine and damage‐associated molecular pattern (DAMP) release in pathophysiology. Haemolysis results in the release of heme into the bloodstream, which can synergize with pathogen‐associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) and Pam3CSK4, that are present during disease. Sensing of these combinations through TLR2 and TLR4 leads to nuclear factor kappa B (NF‐κB) and MAPK signalling, which induce pro‐inflammatory cytokine production, such as tumour necrosis factor (TNF), and IRF1‐mediated upregulation of the cytosolic innate immune sensor NLRP12. These pathways allow NLRP12 to form the PANoptosome and induce inflammatory cell death, PANoptosis. PANoptosis releases more pro‐inflammatory cytokines and DAMPs, which can drive further pathophysiology in the disease.
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