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Review
. 2024 Jan;29(1):125-131.
doi: 10.1007/s10741-023-10356-9. Epub 2023 Oct 3.

Targeting estrogen receptor signaling for treating heart failure

Chenyue Qian  1 , Jingjin Liu #  2   3   4   5   6 , Huadong Liu #  7   8   9   10   11
Affiliations
Review

Targeting estrogen receptor signaling for treating heart failure

Chenyue Qian et al. Heart Fail Rev. 2024 Jan.

Abstract

Heart failure (HF) is a significant public health problem worldwide. It has long been noted that premenopausal women, compared to postmenopausal women and men, have lower rates for developing this disease, as well as subsequent morbidity and mortality. This difference has been attributed to estrogen playing a cardioprotective role in these women, though exactly how it does so remains unclear. In this review, we examine the presence of estrogen receptors within the cardiovascular system, as well as the role they play behind the cardioprotective effect attributed to estrogen. Furthermore, we highlight the underlying mechanisms behind their alleviation of HF, as well as possible treatment approaches, such as hormone replacement therapy and exercise regimens, to manipulate these mechanisms in treating and preventing HF.

Keywords: Cardiac rehabilitation; Estrogen; Estrogen receptor; Heart failure; Hormone replacement therapy.

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Conflict of interest statement

The authors declare no competing interests.

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