Malation
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| Nazivi | |
|---|---|
| Drugi nazivi
Calmathion, Carbethoxy malathion, Carbetovur, Carbetox
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| Identifikacija | |
3D model (Jmol)
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| ChEBI | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.004.089 |
| KEGG[1] | |
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| Svojstva | |
| C10H19O6PS2 | |
| Molarna masa | 330,358 |
| Tačka topljenja | 2.8 |
| Tačka ključanja | 156 |
| Farmakologija | |
| topikalno | |
| Farmakokinetika: | |
| 8-24 h | |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je  ?)
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| Reference infokutije | |
Malation je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 330,358 Da.[4][5][6][7][8]
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 8 |
| Broj donora vodonika | 0 |
| Broj rotacionih veza | 11 |
| Particioni koeficijent[9] (ALogP) | 1,8 |
| Rastvorljivost[10] (logS, log(mol/L)) | -3,3 |
| Polarna površina[11] (PSA, Å2) | 138,3 |
Reference
[уреди | уреди извор]- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Baker EL Jr, Warren M, Zack M, Dobbin RD, Miles JW, Miller S, Alderman L, Teeters WR: Epidemic malathion poisoning in Pakistan malaria workers. Lancet. Baker Jr, E. L.; Warren, M.; Zack, M.; Dobbin, R. D.; Miles, J. W.; Miller, S.; Alderman, L.; Teeters, W. R. (1978 Jan 7). „Epidemic malathion poisoning in Pakistan malaria workers”. Lancet (London, England). 1 (8054): 31—4. PMID 74508. doi:10.1016/s0140-6736(78)90375-6. Проверите вредност парамет(а)ра за датум:
|date=(помоћ) - ^ Bonner MR, Coble J, Blair A, Beane Freeman LE, Hoppin JA, Sandler DP, Alavanja MC: Malathion exposure and the incidence of cancer in the agricultural health study. Am J Epidemiol. ;Bonner, M. R.; Coble, J.; Blair, A.; Beane Freeman, L. E.; Hoppin, J. A.; Sandler, D. P.; Alavanja, M. C. (2007 Nov 1). „Malathion exposure and the incidence of cancer in the agricultural health study”. American Journal of Epidemiology. 166 (9): 1023—34. PMID 17720683. doi:10.1093/aje/kwm182. Проверите вредност парамет(а)ра за датум:
|date=(помоћ) - ^ Edwards JW, Lee SG, Heath LM, Pisaniello DL: Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia. Environ Res. ; Edwards, J. W.; Lee, S. G.; Heath, L. M.; Pisaniello, D. L. (2007 Jan). „Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia”. Environmental Research. 103 (1): 38—45. Bibcode:2007ER....103...38E. PMID 16914134. doi:10.1016/j.envres.2006.06.001. Проверите вредност парамет(а)ра за датум:
|date=(помоћ) - ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. Текст „noedit” игнорисан (помоћ)
- ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. Текст „noedit” игнорисан (помоћ)
- ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. Текст „noedit” игнорисан (помоћ)
- ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. Текст „noedit” игнорисан (помоћ)
- ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. Текст „noedit” игнорисан (помоћ)
Literatura
[уреди | уреди извор]- Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I изд.). Oxford University Press. ISBN 978-0-19-850346-0.
- Smith, Michael B.; March, Jerry (2007). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th изд.). New York: Wiley-Interscience. ISBN 0-471-72091-7.
- Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second изд.). Academic Press. ISBN 0080429882.
Spoljašnje veze
[уреди | уреди извор]- Malathion Архивирано на веб-сајту Wayback Machine (2. март 2014)
