CD14 molecule (Q419553)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08571

Monocyte differentiation antigen CD14

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08571

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

lipopolysaccharide binding

1 reference

26 September 2017

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

opsonin receptor activity

1 reference

8 April 2019

Structure and function of lipopolysaccharide binding protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

lipoteichoic acid binding

1 reference

8 April 2019

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

protein binding

4 references

8 April 2019

SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

IntAct protein interaction database

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

peptidoglycan immune receptor activity

1 reference

8 April 2019

CD14 is a cell-activating receptor for bacterial peptidoglycan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

lipopeptide binding

1 reference

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

lipopolysaccharide binding

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

4 references

8 April 2019

8 April 2019

Human CD14 mediates recognition and phagocytosis of apoptotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

cell surface

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

lipopolysaccharide receptor complex

1 reference

26 September 2017

Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

anchored component of external side of plasma membrane

1 reference

8 April 2019

The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

membrane raft

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

3 references

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

26 September 2017

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

anchored component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

extracellular exosome

4 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

26 September 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

external side of plasma membrane

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

secretory granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

membrane raft

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

lipopolysaccharide receptor complex

extracellular exosome

3 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

toll-like receptor TLR1:TLR2 signaling pathway

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

response to bacterium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

toll-like receptor 4 signaling pathway

ISS

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

cellular response to diacyl bacterial lipopeptide

1 reference

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

response to magnesium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

response to electrical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

MyD88-dependent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

receptor-mediated endocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

cellular response to triacyl bacterial lipopeptide

1 reference

8 April 2019

Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

TRIF-dependent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

positive regulation of endocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

cell surface receptor signaling pathway

1 reference

8 April 2019

CD14 is a cell-activating receptor for bacterial peptidoglycan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

cellular response to lipoteichoic acid

1 reference

8 April 2019

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

phagocytosis

1 reference

8 April 2019

Human CD14 mediates recognition and phagocytosis of apoptotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

positive regulation of tumor necrosis factor production

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

I-kappaB kinase/NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

toll-like receptor TLR6:TLR2 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

cellular response to lipopolysaccharide

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

26 September 2017

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

response to molecule of bacterial origin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

positive regulation of type I interferon production

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

lipopolysaccharide-mediated signaling pathway

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

apoptotic process

1 reference

8 April 2019

Human CD14 mediates recognition and phagocytosis of apoptotic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

necroptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

negative regulation of MyD88-independent toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

apoptotic signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

1 reference

8 April 2019

positive regulation of NIK/NF-kappaB signaling

1 reference

26 September 2017

Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses

http://www.ebi.ac.uk/QuickGO/annotations?protein=P08571&geneProductId=UniProtKB:P08571

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

positive regulation of interferon-gamma production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

toll-like receptor 4 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

cellular response to lipopolysaccharide

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08571

positive regulation of NIK/NF-kappaB signaling

http://purl.uniprot.org/uniprot/P08571

Gene Atlas image

PBB GE CD14 201743 at fs.png
732 × 530; 10 KB

0 references

exact match

1 reference

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P08571

Identifiers

MeSH descriptor ID

D018950

subject named as

Lipopolysaccharide Receptors

0 references

MeSH tree code

D12.776.395.550.448.100

GPI-linked proteins

0 references

D12.776.543.484.500.100

GPI-linked proteins

0 references

D12.776.543.550.418.100

GPI-linked proteins

0 references

D12.776.543.750.705.045

immune receptor

0 references

D23.050.301.264.900.045

myelomonocytic differentiation antigens

0 references

D23.101.100.900.045

myelomonocytic differentiation antigens

0 references

D09.400.430.890.448.100

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID (discontinued)

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

5 August 2016

language of work or name

English

Transporter Classification Database ID

0 references

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023