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CEACAM5

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维基百科，自由的百科全书
CEACAM5
已知的结构
PDB人类UniProt搜索：PDBe RCSB
标识符
代号CEACAM5
扩展标识OMIM：114890；HomoloGene：128801；GeneCards：CEACAM5；OMA：CEACAM5 - orthologs
直系同源
物種人類小鼠
Entrez
1048
无数据
Ensembl
ENSG00000105388
无数据
UniProt
P06731
无数据
mRNA序列
​NM_001291484
​NM_001308398
​NM_004363
无数据
蛋白序列
NP_001278413
​NP_001295327
​NP_004354
无数据
基因位置Chr 19：41.71 – 41.73 Mb无数据
PubMed查询[2]无数据
维基数据
檢視/編輯人類

癌胚抗原相關细胞粘附分子 5 ( Carcinoembryonic antigen-related cell adhesion molecule 5，CEACAM5 )，又稱CD66e ( Cluster of Differentiation 66e)，是癌胚抗原( carcinoembryonic antigen，CEA )基因家族的成員之一。[3]

作用

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文獻中CEACAM5常與癌胚抗原（CEA）同義－－癌胚抗原是多種癌症的生物標記（如大腸直腸癌和非小細胞肺癌）。[4][5]在胚胎腸道和大腸腫瘤中的主要功能是上皮細胞之間的黏附，[6]另外也有抑制大腸細胞分化以及凋亡等作用。[7][8]有證據顯示CEACAM5的高表現與 CD133 陽性的大腸直腸癌幹细胞密切相關。[9]另外，藉由免疫組織化學染色法，發現約 25% 的晚期非鱗狀非小細胞肺癌病人有CEACAM5高表現的現象。[10] [11]

參見

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参考資料

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  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000105388 – Ensembl, May 2017
  2. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5. [2026-06-06]. （原始内容存档于2024-03-28）. 
  4. ^ Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer and Metastasis Reviews. December 2013, 32 (3–4): 643–671. PMID 23903773. S2CID 10344352. doi:10.1007/s10555-013-9444-6. 
  5. ^ Zhang X, Han X, Zuo P, Zhang X, Xu H. CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration. The Journal of International Medical Research. September 2020, 48 (9). PMC 7536504 可免费查阅. PMID 32993395. doi:10.1177/0300060520959478. 
  6. ^ Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule. Cell. April 1989, 57 (2): 327–334. PMID 2702691. S2CID 30740594. doi:10.1016/0092-8674(89)90970-7. 
  7. ^ Ilantzis C, DeMarte L, Screaton RA, Stanners CP. Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia. 2002, 4 (2): 151–163. PMC 1550325 可免费查阅. PMID 11896570. doi:10.1038/sj.neo.7900201. 
  8. ^ Ordoñez C, Screaton RA, Ilantzis C, Stanners CP. Human carcinoembryonic antigen functions as a general inhibitor of anoikis. Cancer Research. July 2000, 60 (13): 3419–3424. PMID 10910050. 
  9. ^ Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells. Cancer Biomarkers. 2021-01-01, 32 (1): 85–98. PMID 34092615. S2CID 235359543. doi:10.3233/CBM-203187. 
  10. ^ LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, et al. Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701).. Journal of Clinical Oncology. 2021-05-20, 39 (15_suppl). ISSN 0732-183X. S2CID 236398737. doi:10.1200/JCO.2021.39.15_suppl.e21030 （英语）. 
  11. ^ Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS. Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates. Frontiers in Oncology. 2023-02-27, 13. PMC 10010383 可免费查阅. PMID 36923424. doi:10.3389/fonc.2023.1124039 可免费查阅. 
取自“https://zh.wikipedia.org/w/index.php?title=CEACAM5&oldid=93528210”