N-Methylclonazepam
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| Formula | C16H12ClN3O3 |
| Molar mass | 329.74 g·mol−1 |
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N-Methylclonazepam (also known as Ro05-4082, ID-690 and methylclonazepam)[1] is a benzodiazepine derivative developed in the 1970s. It has sedative and hypnotic properties, and has around the same potency as clonazepam itself.[2] It was never introduced into clinical use. It is a structural isomer of meclonazepam (3-methylclonazepam), and similarly has been sold as a designer drug, first being identified in Sweden in 2017.[3]
In July 2025, N-methylclonazepam was identified alongside fentanyl as a component in a batch of drugs linked to a mass overdose in Baltimore, Maryland.[4][5] There were at least 27 hospitalisations, and many patients remained unconscious even after administration of naloxone; a NIST research chemist said this may have been due to the sedative effects of the methylclonazepam.[4]
See also
[edit]References
[edit]- ↑ "UNII - 89WG8CN9AJ | UNII Search Service". precision.fda.gov. Retrieved 4 May 2026.
- ↑ Fukuda H, Kudo Y, Ono H, Togari A, Tanaka Y (January 1977). "[Pharmacological study on 5-(o-chlorophenyl)-1-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (ID-690), with special reference to the effects on motor systems]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 73 (1): 123–134. doi:10.1254/fpj.73.123. PMID 558942.
- ↑ "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.
- ↑ Kiefer P (19 July 2025). "Baltimore overdoses may be linked to new drug". The Washington Post. ISSN 0190-8286. Retrieved 4 May 2026.
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