VUF-6002

VUF-6002
(IUPAC) ime
	5-hloro-2-[(4-metilpiperazin-1-il)karbonil]-1H-benzimidazol
Klinički podaci
Identifikatori
CAS broj	869497-75-6
ATC kod	nije dodeljen
PubChem	10446295
Hemijski podaci
Formula	C13H15ClN4O
Mol. masa	278,737 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16) ; Key: MOIWSUQWIOVGRH-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

VUF-6002 (JNJ 10191584) je lek koji deluje kao potentan i selektivan antagonist histaminskog H4 receptora.^[3] On pokazuje antiinflamatorne i analgetske efekte u ispitivanjima akutne inflamacije na životinjama.^[4]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Zhang, M; Thurmond, RL; Dunford, PJ (2007). „The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders”. Pharmacology & therapeutics 113 (3): 594–606. DOI:10.1016/j.pharmthera.2006.11.008. PMID 17275092.
↑ Coruzzi, G; Adami, M; Guaita, E; De Esch, IJ; Leurs, R (2007). „Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation”. European Journal of Pharmacology 563 (1–3): 240–4. DOI:10.1016/j.ejphar.2007.02.026. PMID 17382315.

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