Players who made their Major League debut during the selected season. Player must have appeared in a game as a hitter or a pitcher.
Batting and Pitching statistics for debuts are available since 1957.
| Jiggs Donahue | 1900-09-10 | boxscore | 21.064 | 1B | 6-1 | 178 | L | L | 1879-07-13 | Springfield,OH | MLB | 1900-1909 | 1900-1909 | | premium | premium | premium |
| Mal Eason | 1900-10-01 | boxscore | 21.207 | P | 6-0 | 175 | R | R | 1879-03-13 | Brookville,PA | MLB | 1900-1906 | 1900-1906 | | premium | premium | premium |
| Tom Hughes | 1900-09-07 | boxscore | 21.287 | P | 6-1 | 175 | R | R | 1878-11-29 | Chicago,IL | MLB | 1900-1913 | 1900-1913 | | premium | premium | premium |
| Fred Jacklitsch | 1900-06-06 | boxscore | 24.018 | C | 5-9 | 180 | R | R | 1876-05-24 | Brooklyn,NY | MLB | 1900-1910 | 1900-1910 | | premium | premium | premium |
| Johnny Kling | 1900-09-11 | boxscore | 24.308 | C | 5-10 | 160 | R | R | 1875-11-13 | Kansas City,MO | MLB | 1900-1913 | 1900-1913 | | premium | premium | premium |
| Warren McLaughlin | 1900-07-07 | boxscore | 24.172 | P | | 170 | | L | 1876-01-22 | North Plainfield,NJ | MLB | 1900-1903 | 1900-1903 | | premium | premium | premium |
| Danny Murphy | 1900-09-17 | boxscore | 24.042 | 2B-OF | 5-9 | 175 | R | R | 1876-08-11 | Philadelphia,PA | MLB | 1900-1913 | 1900-1913 | | premium | premium | premium |
| Doc Newton | 1900-04-27 | boxscore | 22.188 | P | 6-0 | 185 | L | L | 1877-10-26 | Mount Carmel,IN | MLB | 1900-1909 | 1900-1909 | | premium | premium | premium |
| Togie Pittinger | 1900-04-26 | boxscore | 28.111 | P | 6-2 | 175 | L | R | 1872-01-12 | Greencastle,PA | MLB | 1900-1907 | 1900-1907 | | premium | premium | premium |
| Ed Poole | 1900-10-06 | boxscore | 26.035 | P | 5-10 | 175 | R | R | 1874-09-07 | Canton,OH | MLB | 1900-1904 | 1900-1904 | | premium | premium | premium |
| Tommy Sheehan | 1900-08-02 | boxscore | 22.274 | 3B | 5-8 | 160 | R | R | 1877-11-06 | Sacramento,CA | MLB | 1900-1908 | 1900-1908 | | premium | premium | premium |
| Dummy Taylor | 1900-08-27 | boxscore | 25.193 | P | 6-1 | 160 | R | R | 1875-02-21 | Oskaloosa,KS | MLB | 1900-1908 | 1900-1908 | | premium | premium | premium |
| 12 record(s) |